T7 Peptide

T7 peptide (Tumstatin (74-98), human) is an endothelial cell-specific inhibitor. T7 peptide interacts with αVβ3 integrin to inhibit the FAK, PI3-kinase, PKB/Akt, and mTOR signaling pathways in endothelial cells, ultimately suppressing protein synthesis and inducing apoptosis[1].

C137H189N33O39S3

3018.36

O=C([C@@H](N)[C@@H](C)O)N[C@H](C(N1[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H]2C(C)C)=O)CC(O)=O)=O)CC(N)=O)=O)C(C)C)=O)CC(N)=O)=O)CSSC[C@H](NC2=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(O)=O)CC(C)C)=O)CC3=CNC4=CC=CC=C34)=O)CC5=CC=C(O)C=C5)=O)CO)=O)CC6=CC=C(O)C=C6)=O)CC(O)=O)=O)CC(N)=O)=O)CCCNC(N)=N)=O)CO)=O)C)=O)CC7=CC=CC=C7)=O)CC(N)=O)=O)=O)CC8=CC=CC=C8)=O)CC(C)C)=O)CC9=CC=CC=C9)=O)CCC1)=O)CCSC

Apoptosis; FAK; Integrin; mTOR

αvβ3

10 mM in DMSO

Room temperature