Tacrine is an effective oral acetylcholine (AChE) inhibitor (IC50 = 109 nM) and also acts as an active substrate for CYP1A2. Tacrine can restore cognitive dysfunction in elderly rats. Tacrine can cause liver toxicity and is used in research related to Alzheimer's disease[1][2][3][4].
CAS Number
[321-64-2]
Molecular Formula
C13H14N2
Molecular Weight
198.27
Smiles
NC1=C2CCCCC2=NC3=CC=CC=C31
Target
Cholinesterase (ChE)
Isoform
AChE
Purity
99.75
Solubility
DMSO : ≥ 100 mg/mL
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)