Tagarafdeg [CAS 2882165-79-7]
Tagarafdeg [CAS 2882165-79-7]
SKU:QM-0151100-01
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Product Details
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Description
Tagarafdeg (CFT1946) is an orally active, CRBN-based and mutant-selective bifunctional degradation activating compound (BiDAC) degrader of BRAFV600E with a DC50 of 14 nM in A375 cells. Tagarafdeg is capable of degrading BRAF V600E (Class I), G469A (Class II), G466V (Class III) mutations, and the p61-BRAFV600E splice variant. Tagarafdeg can be used in tumor research[1][2].
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CAS Number
[2882165-79-7]
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Molecular Formula
C45H49F2N11O9S
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Molecular Weight
958
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Smiles
CN1C(C(C(N(CCC2=O)C(N2)=O)=N1)=C3)=CC(N(CC4)CCC4(O)CC(N5CCC6(C[C@@H](N(C=NC7=CC=C8OC(C(F)=CC=C9N[S](N(C)CC)(=O)=O)=C9C#N)C(C7=C8)=O)CO6)CC5)=O)=C3F
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Target
PROTACs; Raf
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Isoform
B-Raf; Cereblon
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Purity
99.41
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Solubility
DMSO : 100 mg/mL (ultrasonic)
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Storage Conditions
4°C (Powder, protect from light, stored under nitrogen)
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Shipping Conditions
Room Temperature
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Tagarafdeg [CAS 2882165-79-7]
Tagarafdeg is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.