Talaromyketide B is a polyketide compound with anti-inflammatory activity, discovered in the soil bacterium Talaromyces sp. KYS-41. Talaromyketide B inhibits the activation of the NF-κB and MAPK signaling pathways and dose-dependently suppresses pro-inflammatory cytokines, such as IL-1β, IL-6, IL-10, and TNF-α, as well as the transcriptional activity of inflammatory mediators, including iNOS and COX-2. Talaromyketide B holds potential for research in the fields of immunity and inflammatory diseases[1].
Molecular Formula
C15H16O6
Molecular Weight
292.28
Smiles
O=C1C2=CC(OC)=CC(O)=C2C(C(OCC)=O)(O)C=C1C
Target
COX; Interleukin Related; NF-κB; NO Synthase; p38 MAPK; TNF Receptor
