Talarozole (R enantiomer) [CAS 870093-23-5]
Talarozole (R enantiomer) [CAS 870093-23-5]
SKU:QM-0000515
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Product Details
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Description
Talarozole R enantiomer is a potent and selective inhibitor of cytochrome P450 26-mediated breakdown of endogenous all-trans retinoic acid for the treatment of psoriasis and acne. Target: CYP26 in vitro: Talarozole R enantiomer treatment increased the mRNA expression of CRABP2, KRT4, CYP26A1 and CYP26B1 dose dependently, and decreased theexpression of KRT2 and IL-1alpha compared with vehicle-treated skin. No mRNA change in retinol-metabolizing enzymes was obtained. There was no induction of epidermal thickness or overt skin inflammation in talarozole-treated skin. Immunofluorescence analysis confirmed an upregulation of KRT4 protein, but no upregulation of CYP26A1 and CYP26B1 expression was detected [1] [2]. in vivo: Talarozole R enantiomer slightly diffused into the skin only when dissolved in propylene glycol, isopropyl myristate or ethanol. Although only 0.1% of the dose applied was found in the skin itself after 12-24 h, this was sufficient to achieve local concentrations well above the half-maximal inhibitory concentration value for talarozole. The distribution of talarozole within the skin was investigated: 80% was located in the epidermis, while the remaining 20% was found in the dermis [3].
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CAS Number
[870093-23-5]
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Molecular Formula
C21H23N5S
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Molecular Weight
377.51
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Smiles
CCC(CC)[C@H](C1=CC=C(NC2=NC3=CC=CC=C3S2)C=C1)N4N=CN=C4
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Target
Cytochrome P450
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Isoform
CYP26
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Purity
99.7
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Solubility
DMSO : ≥ 51 mg/mL
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Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
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Shipping Conditions
Room Temperature
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Hazard Statement
H302, H315, H319, H335
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Precautions
H302, H315, H319, H335
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Talarozole (R enantiomer) [CAS 870093-23-5]
Talarozole (R enantiomer) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.