Talazoparib-d4

Talazoparib-d4 (BMN-673-d4) is deuterium labeled Talazoparib. Talazoparib (BMN-673) is a highly potent, orally active PARP1/2 inhibitor.Talazoparib inhibits PARP1 and PARP2 enzyme activity with Kis of 1.2 nM and 0.87 nM, respectively. Talazoparib has antitumor activity[1].

C19H10D4F2N6O

384.38

CN1C([C@H]2C(C3=C(N[C@@H]2C4=C(C([2H])=C(F)C([2H])=C4[2H])[2H])C=C(F)C=C35)=NNC5=O)=NC=N1

Isotope-Labeled Compounds; PARP

Room temperature