Taligantinib [CAS 2243235-80-3]

Taligantinib (Compound Example 70) is an orally active and selective dual inhibitor targeting vascular endothelial growth factor receptor 2 (VEGFR-2) and hepatocyte growth factor receptor (c-Met) . Taligantinib suppresses tumor angiogenesis and cell proliferation. Taligantinib is promising for research of solid tumors such as non-small cell lung cancer and hepatocellular carcinoma[1].

[2243235-80-3]

C35H34F2N4O7

660.66

O=C(C1(CC1)C(NC2=CC=C(C(F)=C2)OC3=CC=NC4=CC(OCCCN5CCOCC5)=C6OCCOC6=C43)=O)NC7=CC=C(C=C7)F

C-Met/HGFR; VEGFR

Met; VEGFR2/KDR/Flk-1

Room temperature