Taminadenant [CAS 1337962-47-6]
Taminadenant [CAS 1337962-47-6]
SKU:QM-0136441-01
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Product Details
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Description
Taminadenant (NIR178; PBF509) is a highly potent and orally active adenosine A2A receptor (A2AR) antagonist. Taminadenant can antagonize A2AR agonist-mediated cAMP accumulation and impedance responses with KB values of 72.8 nM and 8.2 nM, respectively. Taminadenant reverses motor impairments in several rat models of movement disorders, including catalepsy, tremor, and hemiparkinsonism. Taminadenant can also inhibit tumor growth when combined with Spartalizumab. Taminadenant reactivate the antitumor immune response[1][2].
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CAS Number
[1337962-47-6]
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Molecular Formula
C10H8BrN7
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Molecular Weight
306.12
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Smiles
BrC(C(N1C=CC=N1)=NC(N2C=CC=N2)=N3)=C3N
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Target
Adenosine Receptor
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Purity
99.84
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Solubility
DMSO : 125 mg/mL (ultrasonic)
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Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
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Shipping Conditions
Room Temperature
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Hazard Statement
H302, H315, H319, H335
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Precautions
H302, H315, H319, H335
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Taminadenant [CAS 1337962-47-6]
Taminadenant is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.