Tau Protein Phosphorylation-IN-1 [CAS 3075165-36-2]
Tau Protein Phosphorylation-IN-1 [CAS 3075165-36-2]
SKU:QM-0013462
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Product Details
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Description
Tau Protein Phosphorylation-IN-1 is a tau protein phosphorylation inhibitor that potently protects PC12 cells against Aβ25–35-induced cytotoxicity (EC50 = 1.93 μM), and can penetrate the blood-brain barrier (BBB) .Tau Protein Phosphorylation-IN-1 reverses the hyperphosphorylation of tau, significantly inhibits the expression of certain immune-related cytotoxic factors, suppresses the MAPK and NF-κB signaling pathways, and significantly inhibits the expression of RAGE and the apoptosis factors Bax/Bcl-2, both in vitro and in vivo. Tau Protein Phosphorylation-IN-1 relieves nerve damage, and improves learning and memory in an Alzheimer’s disease (AD) mouse model. Tau Protein Phosphorylation-IN-1 can be used for AD research[1].
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CAS Number
[3075165-36-2]
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Molecular Formula
C39H56N4O3
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Molecular Weight
628.89
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Smiles
O=C([C@]12[C@](CC(C)(CC2)C)([H])C3=CC[C@@]([C@@]4([C@@](C(C)([C@H](CC4)O)C)([H])CC5)C)([H])[C@]5(C)[C@@]3(CC1)C)OCCN6C(C7=CC=CC=C7)=NN=N6
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Target
Apoptosis; Bcl-2 Family; ERK; JNK; NF-κB; p38 MAPK; Tau Protein
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Shipping Conditions
Room temperature
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Tau Protein Phosphorylation-IN-1 [CAS 3075165-36-2]
Tau Protein Phosphorylation-IN-1 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.