TBIA

TBIA (trans bis-isatoic anhydride) is a covalent RNA crosslinker. TBIA selectively induces RNA tertiary interactions (e.g., multi-helix junctions, loop-helix packing) . TBIA is promising for research of RNA higher-order structure and disease-associated RNAs (e.g., KRAS-mutant RNAs) [1].

C10H4N2O6

248.15

O=C(NC(C1=C2)=CC3=C2NC(OC3=O)=O)OC1=O

DNA/RNA Synthesis

Room temperature