TCIP3 [CAS 3067681-36-8]

TCIP3 is a bivalent molecular glue with with dual binding to p300/CBP and BCL6. TCIP3 redirects p300 and CBP to activate programmed cell death genes normally repressed by the oncogenic driver, BCL6. TCIP3 can be used for the study of diffuse large B cell lymphomas (DLBCLs) . TCIP3 exhibits no toxicity in non-transformed tonsillar lymphocytes or fibroblasts[1].

[3067681-36-8]

C58H71ClF2N16O7

1177.74

O=C(N1CC2=C(CC1)N(C3CCN(CC3)C(CCN4CCN(CC4)C(C5CCN(CC5)C6=NC=C(C(NC7=CC(C=C(C(N8C)=O)OCC(NC)=O)=C8C(OC)=C7)=N6)Cl)=O)=O)N=C2N9C%10=C(CCC9)C=C(C%11=CN(C)N=C%11)C(C(F)F)=C%10)NC

BCL6; Histone Acetyltransferase; Molecular Glues

99.3

DMSO : 100 mg/mL (ultrasonic)

4°C (Powder, protect from light)

Room Temperature