TCL1 (10-24) [CAS 835655-37-3]

TCL1 (10-24) is a encompassing the betaA strand of human TCL1. TCL1 (10-24) is a Akt inhibitor. TCL1 (10-24) interacts with the Akt PH domain prevented phosphoinositide binding and hence inhibits membrane translocation and activation of Akt. TCL1 (10-24) inhibits cellular proliferation and anti-apoptosis. TCL1 (10-24) has tumor growth in vivo[1].

[835655-37-3]

C88H123N23O23

1871.06

O=C(N[C@@H](C(C)C)C(N[C@@H]([C@H](O)C)C(N[C@@H](CC(O)=O)C(N[C@@H](CC1=CNC=N1)C(N2[C@@H](CCC2)C(N[C@@H](CC(O)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(C)C)C(N[C@@H](CC3=CNC4=CC=CC=C34)C(N[C@@H](C)C(N[C@@H](CC5=CNC6=CC=CC=C56)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCCCN)C(N[C@@H](CC7=CC=CC=C7)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](C)N

Akt; Apoptosis

10 mM in DMSO

Room temperature