TCMDC-125457 [CAS 872113-12-7]

TCMDC-125457 is potent in inducing calcium redistribution but minimally inhibits heme crystallization. TCMDC-125457 demonstrated high efficacy when pulsed in a single-dose combination with artesunate against tightly synchronized artemisinin-resistant ring-stage parasites.

[872113-12-7]

C19H18ClN5O3

399.83

ClC1=CC(NC(CN(C(C2=NN(N=C2)C3=CC=CC=C3)=O)C)=O)=C(C=C1)OC

Parasite

10 mM in DMSO

Room temperature