TCO-PEG1-Val-Cit-OH

TCO-PEG1-Val-Cit-OH is a cleavable 1 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1]. TCO-PEG1-Val-Cit-OH is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.

C25H43N5O8

541.64

OC([C@H](CCCNC(N)=O)NC([C@@H](C(C)C)NC(CCOCCNC(OC1CCCC/C=C/C1)=O)=O)=O)=O

ADC Linker

Cleavable Linker; Protease Cleavable Linker

10 mM in DMSO

Room temperature

H302-H315-H319-H335

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501