TD1092 [CAS 3037417-26-5]

TD1092 is a pan-IAP degrader, degrades cIAP1, cIAP2, and XIAP. TD1092 activates Caspase 3/7, and promotes cancer cells apoptosis via IAP degradation. TD1092 inhibits TNFα mediated NF-κB pathway and reduces the phosphorylation of IKK, IkBα, p65, and p38. TD1092 can act as PROTAC, and is used for cancer research[1].

[3037417-26-5]

C55H70N8O9

987.19

O=C(N[C@@H]1CCCC2=C1C=CC=C2)[C@H]3N(C([C@@H](NC([C@H](C)NC)=O)C(C)(C)C)=O)CC4=C(C=CC(OCCCCCCCCNC(C(C5)CN5C(C=C6C7=O)=CC=C6C(N7C8CCC(NC8=O)=O)=O)=O)=C4)C3

Caspase; IAP; PROTACs

Caspase 3; Caspase 7; cIAP-1; cIAP-2; XIAP

99.49

DMSO : ≥ 100 mg/mL

4°C (Powder, protect from light)

Room Temperature