TDO-IN-2

TDO-IN-2 (Compound 5c) is an orally active TDO inhibitor (IC50: 1.25 μM). TDO-IN-2 has antitumor activity in the Hepa1-6 hepatocellular carcinoma allograft mouse model. TDO-IN-2 has synergistic effects with the PD-1/PD-L1 inhibitor BMS-202 and can be used to study tumor immune tolerance[1].

C20H15N3O3

345.35

O=C(/C(C#N)=C/C1=CNC2=CC=CC=C12)NC3=CC(OCCO4)=C4C=C3

Indoleamine 2,3-Dioxygenase (IDO)

Room temperature