TDRL-X80 [CAS 292065-64-6]

TDRL-X80 is a potent inhibitor of xeroderma pigmentosum group A (XPA) protein. TDRL-X80 inhibits XPA’s DNA binding activity. TDRL-X80 exhibits activity against single, double, and Cisplatin-damaged DNA with IC50s of 18, 20, and 29 μM in fluorescence polarization (FP) analyses , and with IC50s of 21, 39, and 28 in ELISA Analysis[1].

[292065-64-6]

C23H15ClN2O6

450.83

O=C(O)C1=CC(C2=CC=C(/C=C3C(C)=NN(C4=CC=CC(C(O)=O)=C4)C\3=O)O2)=CC=C1Cl

DNA/RNA Synthesis

99.6

10 mM in DMSO

-20°C, 3 years; 4°C, 2 years (Powder)

Room Temperature

H302, H413

H302, H413