TEAD-IN-21

TEAD-IN-21 is a potent and orally active pan-TEAD inhibitor with an IC50 of 3 nM. TEAD-IN-21 effectively inhibited the proliferation of Huh-7 cells. TEAD-IN-21 selectively downregulates TEAD-dependent downstream genes. TEAD-IN-21 achieves tumor regression in a liver cancer-derived tumor xenograft mice model. TEAD-IN-21 can be used in the research of hepatocellular carcinoma (HCC) [1].

C16H15F3N6O2S

412.39

CS(=O)(NC1=CC=C(NC2=CC=C(C(F)(F)F)C=C2)C(C3=NN(C)N=N3)=C1)=O

YAP

TEAD

Room temperature