TEC 4

TEC 4 is a ByeTAC (Bypassing E-Ligase-Targeting Chimera) BRD4 degrader, with 33% BRD4 remaining at 500 nM in Ramos B-cells. TEC 4 shows toxicity for Ramos B-cells, with an IC50 of 30.5 nM. ByeTACs directly recruits a protein to the proteasome via interactions with Rpn-13 for degradation. Pink: BRD4 lignad ; Blue: Rpn-13 ligand (HY-159808) ; Black: linker (HY-W008352).

C48H51BrCl2N10O6S2

1078.92

BrC1=CC=C(CC2=NN=C(N2N=C3C4=CC=C(C=C4)Cl)SC3CC(NCCOCCOCCOCCOCCNC(C[C@H]5C6=NN=C(N6C7=C(C(C8=CC=C(C=C8)Cl)=N5)C(C)=C(S7)C)C)=O)=O)C=C1

ByeTAC; Epigenetic Reader Domain

Room temperature