Telapristone acetate [CAS 198414-31-2]

Telapristone acetate (CDB-4124) is a potent progesterone receptor (PR) modulator. Telapristone acetate inhibits the proliferation of ovarian cancer cells by inducing cell cycle arrest and apoptosis. Telapristone effectively inhibits the occurrence and development of spontaneous and chemically induced mammary tumors in rats. Telapristone acetate can be used for breast and ovarian cancer research[1][2].

[198414-31-2]

C31H39NO5

505.65

C[C@@]12[C@](CC[C@]2(OC(C)=O)C(COC)=O)([H])[C@@]3([H])C([C@@H](C4=CC=C(N(C)C)C=C4)C1)=C(CC5)C(CC3)=CC5=O

Apoptosis; CDK; PARP; Progesterone Receptor

10 mM in DMSO

Room temperature