Terfenadine (Standard) [CAS 50679-08-8]
Terfenadine (Standard) [CAS 50679-08-8]
SKU:QM-0159489-01
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Product Details
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Description
Terfenadine (Standard) is the analytical standard of Terfenadine. This product is intended for research and analytical applications. Terfenadine ((±) -Terfenadine) is a potent open-channel blocker of hERG with an IC50 of 204 nM[1]. Terfenadine, an H1 histamine receptor antagonist, acts as a potent apoptosis inducer in melanoma cells through modulation of Ca2+ homeostasis. Terfenadine induces ROS-dependent apoptosis, simultaneously activates Caspase-4, -2, -9[2].
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CAS Number
[50679-08-8]
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Molecular Formula
C32H41NO2
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Molecular Weight
471.67
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Smiles
OC(C1=CC=C(C(C)(C)C)C=C1)CCCN2CCC(C(C3=CC=CC=C3)(O)C4=CC=CC=C4)CC2
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Target
Apoptosis; Caspase; Histamine Receptor; Na+/Ca2+ Exchanger; Potassium Channel; Reference Standards
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Purity
99.91
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Storage Conditions
4°C, sealed storage, away from light and moisture
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Shipping Conditions
Room Temperature
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Hazard Statement
H413
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Precautions
H413
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Terfenadine (Standard) [CAS 50679-08-8]
Terfenadine (Standard) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.