Tesirine (GMP) [CAS 1595275-62-9]
Tesirine (GMP) [CAS 1595275-62-9]
SKU:QM-0005504
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Product Details
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Description
Tesirine (GMP) (SG3249 (GMP) ) is Tesirine produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Tesirine (SG3249) is an antibody-drug conjugate (ADC) pyrrolobenzodiazepine (PBD) dimer payload. Tesirine combines potent antitumor activity with desirable physicochemical properties such as favorable hydrophobicity and improved conjugation characteristics. SG3199 (HY-101161) is the released warhead component of the ADC payload Tesirine. SG3199 retains picomolar activity in a panel of cancer cell lines. PBD dimers are highly efficient DNA minor groove cross-linking agents with potent cytotoxicity[1][2].
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CAS Number
[1595275-62-9]
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Molecular Formula
C75H101N9O23
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Molecular Weight
1496.65
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Smiles
O=C(NC1=CC=C(COC(N2[C@@H](O)[C@@](CC(C)=C3)([H])N3C(C4=CC(OC)=C(OCCCCCOC5=C(OC)C=C6C(N7[C@](CC(C)=C7)([H])C=NC6=C5)=O)C=C42)=O)=O)C=C1)[C@H](C)NC([C@H](C(C)C)NC(CCOCCOCCOCCOCCOCCOCCOCCOCCNC(CCN8C(C=CC8=O)=O)=O)=O)=O
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Target
DNA Alkylator/Crosslinker; Drug-Linker Conjugates for ADC
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Isoform
Pyrrolobenzodiazepines
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Shipping Conditions
Room temperature
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Tesirine (GMP) [CAS 1595275-62-9]
Tesirine (GMP) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.