Tetrahydropiperine [CAS 23434-88-0]
Tetrahydropiperine [CAS 23434-88-0]
SKU:QM-0024301-01
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Product Details
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Description
Tetrahydropiperine is an orally effective, selective inhibitor of NF-κB and MAPKs, and an activator of the PI3K/Akt/mTOR pathway. Tetrahydropiperine reduces the production of pro-inflammatory cytokines such as TNF-α, IL-6, and nitric oxide (NO) by inhibiting the nuclear translocation of NF-κB and the phosphorylation of MAPKs such as ERK, JNK, and p38. At the same time, Tetrahydropiperine inhibits excessive autophagy by activating the PI3K/Akt/mTOR pathway, protecting neurons from oxidative damage. Tetrahydropiperine has anti-inflammatory, anti-apoptotic, and neuroprotective effects, and is mainly used in the study of inflammatory diseases (such as endotoxemia, arthritis) and neurological diseases such as ischemic stroke[1][2][3].
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CAS Number
[23434-88-0]
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Molecular Formula
C17H23NO3
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Molecular Weight
289.37
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Smiles
O=C(N1CCCCC1)CCCCC2=CC=C(OCO3)C3=C2
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Target
Cytochrome P450
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Isoform
CYP1
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Purity
99.41
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Solubility
DMSO : 100 mg/mL (ultrasonic)
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Storage Conditions
4°C (Powder, protect from light)
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Shipping Conditions
Room Temperature
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Hazard Statement
H302, H315, H319, H335
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Precautions
H302, H315, H319, H335
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Tetrahydropiperine [CAS 23434-88-0]
Tetrahydropiperine is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.