Tetramisole [CAS 5036-02-2]

Tetramisole is an orally active, selective inward rectifier potassium channel agonist with an EC50 of approximately 30 μM for the Kir2.1 subunit. Tetramisole is also an anti-nematode agent that blocks neuromuscular transmission by non-competitive depolarization. Tetramisole promotes the forward transport of Kir2.1 channels, hyperpolarizes the resting potential (RP), shortens the action potential duration (APD), inhibits intracellular calcium overload and the PKA signaling pathway, and exerts anti-arrhythmic and anti-myocardial remodeling activities. Tetramisole can be used in cardiac electrophysiology research and research related to myocardial ischemia and heart failure[1][2].

[5036-02-2]

C11H12N2S

204.29

C12=NC(C3=CC=CC=C3)CN1CCS2

Parasite; PKA; Potassium Channel

Inwardly rectifying potassium channel

Room temperature