Tetrazine-PEG4-biotin

Tetrazine-PEG4-biotin is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1]. Tetrazine-PEG4-biotin is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.

C30H44N8O7S

660.78

O=C(CCOCCOCCOCCOCCNC(CCCC[C@@H]1SC[C@H](N2)[C@@H]1NC2=O)=O)NCC(C=C3)=CC=C3C4=NN=CN=N4

ADC Linker

Cleavable Linker

99.34

10 mM in DMSO

-20°C (Powder, protect from light)

Blue Ice

H302, H315, H319, H335

H302, H315, H319, H335