TfR-1-IN-1 [CAS 1643444-62-5]

TfR-1-IN-1 (compound C4) is an inhibitor of transferrin receptor 1 (TfR-1) with anticancer activity. TfR-1-IN-1 strongly increases intracellular iron (II) levels as a driving force for the induction of ferroptosis. TfR-1-IN-1 significantly reduces the metabolic activity of ovarian cancer (A2780cis), breast cancer (MDA-MB 231), and leukemia (HL-60) cell lines with IC50 values ​​of 0.51, 0.46, and 0.48 μM, respectively[1].

[1643444-62-5]

C20H12ClF2FeN2O2

441.62

FC1=CC=CC2=C1C=[N]3C4=CC=CC=C4[N]5=CC6=C(F)C=CC=C6[O-][Fe+3]5([Cl-])3[O-]2

Ferroptosis; Transferrin Receptor

96.96

DMSO : 20 mg/mL (ultrasonic)

-20°C, 3 years; 4°C, 2 years (Powder)

Room Temperature