TGF-β2-IN-1

TGF-β2-IN-1 is a selective TGF-β2 inhibitor. TGF-β2-IN-1 exhibits potent antiproliferative effects on HCT-116, Caco-2 and HT-29 with IC50 values of 6.84, 10.21, and 9.47 μM, respectively. TGF-β2-IN-1 inhibits TGF-β2 signaling in a dose-dependent manner by suppressing both receptor and cytokine expression.TGF-β2-IN-1 can be used for the study of colorectal cancer[1].

C25H22ClN5O3

475.93

COC1=CC=CC(/C=N/NC(C2=CC=CC=C2OCC3=CN(N=N3)CC4=CC(Cl)=CC=C4)=O)=C1

TGF-beta/Smad

Room temperature