TH-Z827 [CAS 2847881-81-4]

TH-Z827 is a mutant selective KRAS (G12D) inhibitor with an IC50 of 2.4 μM. TH-Z827 does not bind KRAS (WT) or KRAS (G12C) . TH-Z827 blocked the KRAS (G12D) -CRAF interaction with an IC50 value of 42 μM[1].

[2847881-81-4]

C30H38N6O

498.66

CN(CCC1)[C@@H]1COC2=NC(N3[C@@H]4CNC[C@H]3CC4)=C5C(CN(C6=CC=CC7=C6C(C)=CC=C7)CC5)=N2

Ras

K-Ras

95.12

DMSO : 100 mg/mL (ultrasonic)

-20°C, 3 years; 4°C, 2 years (Powder)

Room Temperature