Thalidomide-4-NH-PEG1-COOH (TFA) [CAS 2140807-20-9]

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Description
Thalidomide-4-NH-PEG1-COOH TFA is an E3 Ligase Ligand-Linker Conjugate consisting of Thalidomide and NH-PEG3-NH-Boc. Thalidomide-4-NH-PEG1-COOH TFA acts as a ligand for Cereblon to recruit CRBN protein. Thalidomide-4-NH-PEG1-COOH TFA is a key intermediate in the synthesis of CRBN-based PROTAC molecules.
CAS Number
[2140807-20-9]
Molecular Formula
C20H20F3N3O9
Molecular Weight
503.38
Smiles
O=C(O)CCOCCNC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O.O=C(O)C(F)(F)F
Target
Apoptosis; Autophagy; E3 Ligase Ligand-Linker Conjugates
Isoform
Cereblon
Solubility
10 mM in DMSO
Shipping Conditions
Room temperature
Hazard Statement
H302-H315-H319-H335
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Thalidomide-4-NH-PEG1-COOH (TFA) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.