Thalidomide-4-NH-PEG2-COO (t-Bu) [CAS 2140807-16-3]

Thalidomide-4-NH-PEG2-COO (t-Bu) is a t-Bu modified Thalidomide , which acts as a Cereblon ligand to recruit CRBN protein. The t-Bu protecting group at the end of Thalidomide-4-NH-PEG2-COO (t-Bu) can be removed under acidic conditions to participate in the synthesis of PROTAC molecules. Thalidomide-4-NH-PEG2-COO (t-Bu) is a key intermediate in the synthesis of CRBN-based PROTAC molecules.

[2140807-16-3]

C24H31N3O8

489.52

O=C(OC(C)(C)C)CCOCCOCCNC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O

Apoptosis; Autophagy; E3 Ligase Ligand-Linker Conjugates

Cereblon

10 mM in DMSO

Room temperature

H302-H315-H319-H335

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501