Thalidomide inhibits cereblon (CRBN), a part of the cullin-4 E3 ubiquitin ligase complex CUL4-RBX1-DDB1, with a Kd of ∼250 nM, and has immunomodulatory, anti-inflammatory and anti-angiogenic cancer properties. Thalidomide can work as molecular glue to potentiate substrate.
CAS Number
[50-35-1]
Molecular Formula
C13H10N2O4
Molecular Weight
258.23
Smiles
O=C1N(C2CCC(NC2=O)=O)C(C3=CC=CC=C31)=O
Target
Apoptosis; Autophagy; Ligands for E3 Ligase; Molecular Glues