Thalidomide-NH- (CH2) 2-NH-Boc [CAS 1957235-57-2]
Thalidomide-NH- (CH2) 2-NH-Boc [CAS 1957235-57-2]
SKU:QM-0124446-01
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Product Details
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Description
Thalidomide-NH- (CH2) 2-NH-Boc is a Boc-modified Thalidomide that acts as a Cereblon ligand to recruit CRBN protein. The Boc protecting group at the end of Thalidomide-NH- (CH2) 2-NH-Boc can be removed under acidic conditions to participate in the synthesis of PROTAC molecules. Thalidomide-NH- (CH2) 2-NH-Boc is a key intermediate in the synthesis of CRBN-based PROTAC molecules.
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CAS Number
[1957235-57-2]
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Molecular Formula
C20H24N4O6
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Molecular Weight
416.43
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Smiles
O=C(OC(C)(C)C)NCCNC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O
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Target
Apoptosis; Autophagy; E3 Ligase Ligand-Linker Conjugates
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Isoform
Cereblon
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Solubility
10 mM in DMSO
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Shipping Conditions
Room temperature
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Hazard Statement
H302-H315-H319-H335
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Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Thalidomide-NH- (CH2) 2-NH-Boc [CAS 1957235-57-2]
Thalidomide-NH- (CH2) 2-NH-Boc is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.