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Thalidomide-NH- (CH2) 2-NH2 (TFA) [CAS 1957235-67-4]

Thalidomide-NH- (CH2) 2-NH2 (TFA) [CAS 1957235-67-4]

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QM-0094789

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Product Details

  • Description

    Thalidomide-NH- (CH2) 2-NH2 TFA is an alkyl-modified Thalidomide that acts as a Cereblon ligand to recruit CRBN proteins. Thalidomide-NH- (CH2) 2-NH2 TFA is a key intermediate in the synthesis of CRBN-based PROTAC molecules designed to synthesize small PROTAC molecules targeting SHP2 protein.

  • CAS Number

    [1957235-67-4]

  • Molecular Formula

    C17H17F3N4O6

  • Molecular Weight

    430.34

  • Smiles

    O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC=C3NCCN)=O.O=C(O)C(F)(F)F

  • Target

    Apoptosis; Autophagy; E3 Ligase Ligand-Linker Conjugates

  • Isoform

    Cereblon

  • Solubility

    10 mM in DMSO

  • Shipping Conditions

    Room temperature

  • Hazard Statement

    H302-H315-H319-H335

  • Precautions

    P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Thalidomide-NH- (CH2) 2-NH2 (TFA) [CAS 1957235-67-4]

Thalidomide-NH- (CH2) 2-NH2 (TFA) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.