Thalidomide-NH-PEG3-NH-Boc [CAS 2204246-03-5]
Thalidomide-NH-PEG3-NH-Boc [CAS 2204246-03-5]
SKU:QM-0156259-01
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Product Details
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Description
Thalidomide-NH-PEG3-NH-Boc is an E3 Ligase Ligand-Linker Conjugate consisting of Thalidomide and NH-PEG3-NH-Boc. Thalidomide-NH-PEG3-NH-Boc acts as a ligand for Cereblon to recruit CRBN protein. The Boc protecting group at the end of Thalidomide-NH-PEG3-NH-Boc can be removed under acidic conditions to participate in the synthesis of PROTAC molecules. Thalidomide-NH-PEG3-NH-Boc is a key intermediate in the synthesis of CRBN-based PROTAC molecules.
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CAS Number
[2204246-03-5]
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Molecular Formula
C26H36N4O9
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Molecular Weight
548.59
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Smiles
O=C(OC(C)(C)C)NCCOCCOCCOCCNC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O
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Target
Apoptosis; Autophagy; E3 Ligase Ligand-Linker Conjugates
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Isoform
Cereblon
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Purity
97.2
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Solubility
DMSO : 100 mg/mL (ultrasonic)
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Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
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Shipping Conditions
Room Temperature
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Hazard Statement
H302, H315, H319, H335
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Precautions
H302, H315, H319, H335
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Thalidomide-NH-PEG3-NH-Boc [CAS 2204246-03-5]
Thalidomide-NH-PEG3-NH-Boc is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.