Thalidomide-O-amido-C4-N3 [CAS 2098488-36-7]

Thalidomide-O-amido-C4-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. Thalidomide-O-amido-C4-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

[2098488-36-7]

C19H20N6O6

428.4

O=C(N(C(CCC1=O)C(N1)=O)C2=O)C(C2=CC=C3)=C3OCC(NCCCCN=[N+]=[N-])=O

Apoptosis; Autophagy; E3 Ligase Ligand-Linker Conjugates

Cereblon

98.36

DMSO : ≥ 41 mg/mL

4°C (Powder, stored under nitrogen)

Room Temperature

H302, H315, H319, H335

H302, H315, H319, H335