Thalidomide-O-amido-C8-NH2 [CAS 1950635-15-0]

Thalidomide-O-amido-C8-NH2 (Cereblon Ligand-Linker Conjugates 2), a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker, can be used in the synthesis of PROTACs[1].

[1950635-15-0]

C23H30N4O6

458.51

NCCCCCCCCNC(COC1=C(C(N2C(CCC3=O)C(N3)=O)=O)C(C2=O)=CC=C1)=O

Apoptosis; Autophagy; E3 Ligase Ligand-Linker Conjugates

Cereblon

10 mM in DMSO

Room temperature

H315-H319-H320

P264-P280-P302+P352-P305+P351+P338-P362