Thiazoplanomicin

Thiazoplanomicin (Compound 1) is a thiazolyl peptide antibiotic. Thiazoplanomicin can be isolated from the leaf-litter actinomycete Actinoplanes sp. MM794L-181F6. Thiazoplanomicin has potent antimicrobial activities against gonococcal strains (especially drug-resistant strains) and Gram-positive bacterium with MICs of 31.2-125 and 0.5-15.6 ng/mL, respectively. Thiazoplanomicin has no antibacterial activity against E.coli. Thiazoplanomicin can be used for bacterial infections research[1].

C50H39N13O16S5

1238.25

O=C(NC(C(N)=O)=O)C1=CSC(C2=NC(C3=CSC4=N3)=C(C5=NC(C(N[C@@](C(N/C(C6=NC(C(N[C@@](C7=NC=C(C(N[C@@]4([H])COC8=O)=O)S7)([H])[C@](C(O)C(OC9)=O)([H])OCC%10=C8N(O)C%11=C%10C9=CC=C%11)=O)=CS6)=C/C)=O)([H])C(C)([H])O)=O)=CS5)C=C2O)=N1

Antibiotic; Bacterial

Room temperature