Thiorphan [CAS 76721-89-6]

Thiorphan is a selective neprilysin (NEP) inhibitor with an IC50 of 6.9 nM. Thiorphan competitively binds to NEP and blocks its activity, preventing the degradation of neuropeptides such as substance P (SP) and neurokinin NKA. In the field of neonatal brain injury research, Thiorphan can increase the levels of SP and NKA, activate NK1 and NK2 receptors and downstream transduction pathways, and inhibit excessive activation of NMDA receptors. Thus, Thiorphan can protect neocortical neurons from excitotoxic cell death. Thiorphan may also inhibit NEP from enhancing bronchoconstriction and can be used in the study of respiratory diseases[1][2][3].

[76721-89-6]

C12H15NO3S

253.32

SCC(C(NCC(O)=O)=O)CC1=CC=CC=C1

Neprilysin

99.94

DMSO : 175 mg/mL (ultrasonic)

-20°C (Powder, protect from light)

Blue Ice

H302, H315, H319, H335

H302, H315, H319, H335