THIP (Gaboxadol) is a selective extrasynaptic GABAA receptors (eGABARs) agonist (with blood-brain barrier permeability), shows an EC50 value of 13 μM for δ-GABAAR. THIP induces strong tense GABAA-mediated currents in layer 2/3 neurons, but shows on effect on miniature IPSCs. THIP can be used in studies of sleep disorders[1][2][3].
CAS Number
[64603-91-4]
Molecular Formula
C6H8N2O2
Molecular Weight
140.14
Smiles
O=C1C2=C(CNCC2)ON1
Target
GABA Receptor
Concentration
10mM
Purity
99.93
Solubility
DMSO : 50 mg/mL (ultrasonic; adjust pH to 3 with HCl) |H2O : 23.33 mg/mL (ultrasonic)