α-Thujone [CAS 546-80-5]

α-Thujone is a monoterpene isolated from Thuja occidentalis essential oil with potent anti-tumor activities. α-Thujone is a reversible modulator of the GABA type A receptor and the IC50 for α-Thujone is 21 μM in suppressing the GABA-induced currents. α-Thujone induces ROS accumulation-dependent cytotoxicity, also induces cell apoptosis and autophagy. α-Thujone has antinociceptive, insecticidal, and anthelmintic activity, and can cross the blood-brain barrier[1][2][3].

[546-80-5]

C10H16O

152.24

O=C1C[C@]2(C(C)C)C[C@]2([H])[C@H]1C

Apoptosis; Autophagy; GABA Receptor; Parasite; Reactive Oxygen Species (ROS)

98.07

DMSO : 100 mg/mL (ultrasonic)

-20°C, 3 years; 4°C, 2 years (Powder)

Room Temperature

H302

H302