Tianeptine-d12 [CAS 1189870-26-5]

Tianeptine-d12 is a deuterated analog of Tianeptine.Tianeptine is an atypical antidepressant. Tianeptine is a moderate-intensity agonist of the μ-opioid receptor (MOR), and to a lesser extent, is an agonist of the δ-opioid receptor (DOR). Tianeptine is a glutamate modulator that can enhance AMPA receptor and antagonize NMDA receptor. Tianeptine increases sensitivity of the α1 adrenergic receptor, which only manifests in chronic treatment. Tianeptine exerts neuroprotective effects under stress/inflammation-induced conditions, exhibiting anti-inflammatory and antioxidant properties. Tianeptine inhibits MMP-9 by suppressing the PI3K/Akt-mediated NF-κB pathway. Tianeptine can be used to alleviate symptoms of depression and anxiety, but does not cause sedative effects.

[1189870-26-5]

C21H13D12ClN2O4S

449.03

N(C(C(C(C(C(C(C(O)=O)([2H])[2H])([2H])[2H])([2H])[2H])([2H])[2H])([2H])[2H])([2H])[2H])C1C=2C(S(=O)(=O)N(C)C=3C1=CC=CC3)=CC(Cl)=CC2

Akt; iGluR; Isotope-Labeled Compounds; MMP; NF-κB; Opioid Receptor; PI3K

10 mM in DMSO

Room temperature