TIM-3-IN-2 [CAS 1113126-49-0]

TIM-3-IN-2 (Compound A-41) is a Tim3 inhibitor (KD: 0.61 μM) . TIM-3-IN-2 blocks TIM-3 interactions with PtdSer, CEACAM1, and Gal-9. TIM-3-IN-2 inhibits the immunosuppressive function of TIM-3. TIM-3-IN-2 reverses the TIM-3-mediated blockade of the production of proinflammatory cytokines, and maximizes the T-cell antitumor activity against AML cell lines[1].

[1113126-49-0]

C25H23N3O6

461.47

O=C(NC1=C(C=C(C=C1)OC)OC)COC2=CC=CC(C3=NC(C4=CC=C(C=C4)OC)=NO3)=C2

Tim3

98.93

DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C)

-20°C, 3 years; 4°C, 2 years (Powder)

Room Temperature