Tinlorafenib [CAS 2573781-75-4]
Tinlorafenib [CAS 2573781-75-4]
SKU:QM-0149393-01
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Product Details
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Description
Tinlorafenib (PF-07284890) is the orally active inhibitor for BRAF and CRAF with IC50s of 5.8 nM and 4.1 nM. Tinlorafenib (Compound 10) inhibits V600E mutated BRAF and V600K mutanted BRAF with IC50s of 4.25 nM and 2.7 nM. Tinlorafenib can cross the blood brain barrier. Tinlorafenib demonstrates CNS penetration and can be used in the research of BRAF-associated malignant and benign tumors of the CNS as well as extracranial malignancies[1][2].
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CAS Number
[2573781-75-4]
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Molecular Formula
C19H19ClF2N4O3S
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Molecular Weight
456.89
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Smiles
O=C1C2=C(C=CC(NC3=C(Cl)C(NS(=O)(CCCF)=O)=CC=C3F)=C2C)N=CN1C
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Target
ERK; Raf
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Isoform
B-Raf
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Concentration
10mM
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Purity
98.21
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Solubility
DMSO : 125 mg/mL (ultrasonic)
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Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
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Shipping Conditions
Room Temperature
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Tinlorafenib [CAS 2573781-75-4]
Tinlorafenib is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.