TJU103 [CAS 10245-44-0]

TJU103 is a CD4 inhibitor. TJU103 inhibits autoreactive CD4+ T cells by disrupting the function of the CD4 during activation. TJU103 decreases mononuclear cell infiltration in brain and spinal cord tissue of experimental allergic encephalomyelitis (EAE) mice model. TJU103 downregulates Th1 and Th2 cytokine levels in response to proteolipid protein epitope 139-151 (PLPe) and exhibits inhibitory effects both after the appearance of EAE symptoms and upon rechallenge with Ag. TJU103 can be used for autoimmune diseases like EAE and sclerosis (MS) research[1].

[10245-44-0]

C15H12N4O

264.28

O=C(C1=CC=NC=C1)N/N=C/C2=CNC3=C2C=CC=C3

Transmembrane Glycoprotein

Room temperature

H302-H315-H319-H335

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501