TLQP-21 [CAS 869988-94-3]

TLQP-21, a VGF-derived peptide endowed of endocrine and extraendocrine properties, is a potent G-protein-coupled receptor complement-3a receptor 1 (C3aR1) agonist (EC50: mouse TLQP-21=10.3 μM; human TLQP-21=68.8 μM) . TLQP-21 activates C3aR1 to induce an increase of intracellular Ca2+. TLQP-21 is used for the research in regulation of nociception and other relevant physiologic functions[1][2].

[869988-94-3]

C107H170N40O26

2432.75

C(=O)([C@H]1N(C([C@@H](NC([C@@H](NC([C@H](CC2=CN=CN2)NC([C@H](CC3=CN=CN3)NC([C@H](CC4=CC=CC=C4)NC([C@H](CC5=CN=CN5)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(=O)[C@H]6N(C(=O)[C@H]7N(C([C@@H](NC([C@@H](NC([C@H]([C@@H](C)O)N)=O)CC(C)C)=O)CCC(N)=O)=O)CCC7)CCC6)C)=O)CO)=O)CO)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)=O)=O)=O)=O)C)=O)CC(C)C)=O)CCC1)N8[C@H](C(N[C@H](C(N[C@@H](CCCNC(=N)N)C(O)=O)=O)C)=O)CCC8

Complement System

H2O

Room temperature