TLQP-21 (TFA)

TLQP-21 TFA, a VGF-derived peptide endowed of endocrine and extraendocrine properties, is a potent G-protein-coupled receptor complement-3a receptor1 (C3aR1) agonist (EC50: mouse TLQP-21=10.3 μM; human TLQP-21=68.8μM) . TLQP-21 TFA activates C3aR1 to induce an increase of intracellular Ca2+. TLQP-21 TFA is used for the research in regulation of nociception and other relevant physiologic functions[1][2].

C109H171F3N40O28

2546.77

O=C(N1[C@@H](CCC1)C(N[C@@H](C)C(N[C@H](C(O)=O)CCCNC(N)=N)=O)=O)[C@H]2N(CCC2)C([C@H](CC(C)C)NC([C@H](C)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](CO)NC([C@H](CO)NC([C@H](C)NC([C@H]3N(CCC3)C([C@H]4N(CCC4)C([C@H](CCC(N)=O)NC([C@H](CC(C)C)NC([C@@H](N)[C@H](O)C)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CC5=CN=CN5)=O)CC6=CC=CC=C6)=O)CC7=CN=CN7)=O)CC8=CN=CN8)=O)=O)=O.O=C(O)C(F)(F)F

Complement System

99.9

H2O : 50 mg/mL (ultrasonic)

-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

Blue Ice