TLR4/NF-κB-IN-1 [CAS 3050836-94-4]

TLR4/NF-κB-IN-1 (Compound 7x) is an orally available inhibitor that specifically targets the TLR4/NF-κB signaling pathway, offering anti-inflammatory effects and the ability to cross the blood-brain barrier. TLR4/NF-κB-IN-1 can reduce acute neuroinflammation in mice caused by LPS and downregulate the expression of TLR4, P-NF-κB and P-IκB-α proteins[1].

[3050836-94-4]

C20H15FN6O

374.37

FC1=CC=C(CN2C=CC3=C(NC4=CC(NC(N5)=O)=C5C=C4)N=CN=C32)C=C1

IKK; NF-κB; Toll-like Receptor (TLR)

TLR4

99.92

DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)

-20°C, 3 years; 4°C, 2 years (Powder)

Room Temperature