TMX-4102

TMX-4102 is a highly selective phosphatidylinositol 5-phosphate 4-kinase type II gamma (PIP4K2C) binder. TMX-4102 has binding activity to PIP4K2C (KD = 0.45 nM) and has no significant effect on other lipid and non-lipid kinases.TMX-4102 specifically binds to PIP4K2C, regulating its scaffold function rather than its enzymatic activity. TMX-4102 can be used as a tool molecule to study the biological function and potential therapeutic value of PIP4K2C[1].

C26H20ClN5O2

469.92

ClC1=CN=C(NC2=CC3=C(OC[C@]([H])(CC4)N3C4=O)N=C2)N=C1C5=CC=CC(C6=CC=CC=C6)=C5

PI5P4K

Room temperature