TNF-α-IN-18 [CAS 1272322-42-5]

TNF-α-IN-18 (Compound 61) is an inhibitor for TNF-α (IC50 of 1.8 μM), that inhibits TNF signaling pathway through block of NF-kB migration from cytoplasm to nucleus. TNF-α-IN-18 exhibits slight cytotoxicity to mouse fibroblast LM cell, with a CC50 >50 μM. TNF-α-IN-18 ameliorates the TNF- or Lipopolysaccharide -induced sepsis in mouse models. TNF-α-IN-18 protects mice from rheumatoid arthritis[1].

[1272322-42-5]

C16H7ClF2O4

336.67

O=C(C1=C(C2=C(F)C=CC(F)=C2)OC3=CC(Cl)=CC=C3C1=O)O

NF-κB; TNF Receptor

98.94

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