TNF-α-IN-25

TNF-α-IN-25 is an orally active TNF-α inhibitor. TNF-α-IN-25 shows Fluorescence Polarization (FP) assay IC50 of 103 nM in FP binding assays and L929 assay IC50 of 505 nM in cell-based assays. TNF-α-IN-25 inhibits paw swelling in the glucose-6-phosphate isomerase (GPI) arthritis model. TNF-α-IN-25 can be used for the study of arthritis[1].

C23H21FN6O

416.45

CC(O)(C1=NC=C(C=N1)C2=CC=C3N=C4CN5CC6=C([C@H](N4C3=N2)C5)C(F)=CC=C6)C

TNF Receptor

Room temperature